Effect of Anger Patterns and Depression on Serum IgA and NK Cell Frequency

Background: There are conflicting findings about relationship between depression and anger with immunological parameters. Objective: To investigate the relationship between anger patterns and immune system in depressed patients. Methods: Thirty-five patients with major depressive disorder were selected according to DSM-IV criteria. The Hamilton Depression Scale and Spielberger Anger questionnaires were used to determine severity of depression and "anger expression pattern", respectively. The control group without a previous history of mental illness was also selected. In the group of patients with moderate depression, serum IgA levels and NK cell percentage were measured. Results: Mean differences of all types of "anger expression pattern", including; "state-trait anger", "anger expression out", "anger expression in", "anger control out" and "anger control in", between study and control groups, were statistically significant (p